Cryo-EM reveals two distinct serotonin-bound conformations of full-length 5-HT(3A) receptor

Serotonin receptor (5-HT(3A)R)(1), a cationic pentameric ligand-gated ion channel (pLGIC), is the clinical target for management of nausea and vomiting associated with radiation and chemotherapies(2). Upon binding, serotonin induces a global conformational change encompassing the ligand-binding extr...

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Bibliographic Details
Published in:Nature
Main Authors: Basak, Sandip, Gicheru, Yvonne, Rao, Shanlin, Sansom, Mark S.P, Chakrapani, Sudha
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237196/
https://ncbi.nlm.nih.gov/pubmed/30401837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0660-7
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