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Cryo-EM structure of full-length HIV-1 Env bound with the Fab of antibody PG16

The HIV-1 envelope protein (Env) is the target of neutralizing antibodies and the template for vaccine immunogen design. The dynamic conformational equilibrium of trimeric Env influences its antigenicity and potential immunogenicity. Antibodies that bind at the trimer apex stabilize a “closed” confo...

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Detalles Bibliográficos
Publicado en:J Mol Biol
Autores principales: Pan, Junhua, Peng, Hanqin, Chen, Bing, Harrison, Stephen C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7058448/
https://ncbi.nlm.nih.gov/pubmed/31931014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2019.11.028
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