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Resistance mechanisms to SYK inhibition in acute myeloid leukemia
Spleen tyrosine kinase (SYK) is a non-mutated therapeutic target in acute myeloid leukemia (AML). Attempts to exploit SYK therapeutically in AML have shown promising results in combination with chemotherapy, likely reflecting induced mechanisms of resistance to single agent treatment in vivo. We con...
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| Published in: | Cancer Discov |
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| Main Authors: | , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2019
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7058374/ https://ncbi.nlm.nih.gov/pubmed/31771968 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-0209 |
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