Inflammatory signaling pathways play a role in SYK inhibitor resistant AML

Abstract Trials have shown promising clinical activity of the selective SYK inhibitor entospletinib in patients with high expressing HOXA9/MEIS1 acute leukemias. As the development of resistance mechanisms is a common problem in the use of targeted drugs, we performed a chemical library screen to id...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Sarah Tausch, Christina Villinger, Gabriela Alexe, Daniel J. Urban, Min Shen, Dominique Jahn, Jonas Vischedyk, Sebastian Scheich, Hubert Serve, Matthew D. Hall, Kimberly Stegmaier, Thomas Oellerich, Anjali Cremer
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Portfolio 2025-04-01
Colección:Scientific Reports
Materias:
Acute myeloid leukemia cells
Resistance
Inflammatory pathways
Glucocorticoids
Acceso en línea:https://doi.org/10.1038/s41598-025-96660-w
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares