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Integrating Hydrogen-Deuterium exchange mass spectrometry with Molecular Dynamics simulations to probe lipid-modulated conformational changes in membrane proteins

Biological membranes provide the medium through which membrane proteins move and function. It has become increasingly evident that direct interactions of membrane proteins with their surrounding lipids play key roles in regulating both protein conformations and function. However, the exact nature an...

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Foilsithe in:Nat Protoc
Main Authors: Martens, Chloe, Shekhar, Mrinal, Lau, Andy, Tajkhorshid, Emad, Politis, Argyris
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7058097/
https://ncbi.nlm.nih.gov/pubmed/31605097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41596-019-0219-6
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