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Integrating Hydrogen-Deuterium exchange mass spectrometry with Molecular Dynamics simulations to probe lipid-modulated conformational changes in membrane proteins

Biological membranes provide the medium through which membrane proteins move and function. It has become increasingly evident that direct interactions of membrane proteins with their surrounding lipids play key roles in regulating both protein conformations and function. However, the exact nature an...

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Detalhes bibliográficos
Publicado no:Nat Protoc
Main Authors: Martens, Chloe, Shekhar, Mrinal, Lau, Andy, Tajkhorshid, Emad, Politis, Argyris
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7058097/
https://ncbi.nlm.nih.gov/pubmed/31605097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41596-019-0219-6
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