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Direct protein-lipid interactions shape the conformational landscape of secondary transporters
Secondary transporters undergo structural rearrangements to catalyze substrate translocation across the cell membrane – yet how such conformational changes happen within a lipid environment remains poorly understood. Here, we combine hydrogen-deuterium exchange mass spectrometry (HDX-MS) with molecu...
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| Pubblicato in: | Nat Commun |
|---|---|
| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6175955/ https://ncbi.nlm.nih.gov/pubmed/30297844 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06704-1 |
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