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Mutation Profiles in Glioblastoma 3D Oncospheres Modulate Drug Efficacy

Glioblastoma (GBM) is a lethal brain cancer with a median survival time of approximately 15 months following treatment. Common in vitro GBM models for drug screening are adherent and do not recapitulate the features of human GBM in vivo. Here we report the genomic characterization of nine patient de...

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Detalhes bibliográficos
Publicado no:SLAS Technol
Main Authors: Wilson, Kelli M., Mathews-Griner, Lesley A., Williamson, Tara, Guha, Rajarshi, Chen, Lu, Shinn, Paul, McKnight, Crystal, Michael, Sam, Klumpp-Thomas, Carleen, Binder, Zev A., Ferrer, Marc, Gallia, Gary L., Thomas, Craig J., Riggins, Gregory J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7058093/
https://ncbi.nlm.nih.gov/pubmed/30289729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2472630318803749
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