Influence of Casein kinase II inhibitor CX-4945 on BCL6-mediated apoptotic signaling in B-ALL in vitro and in vivo

BACKGROUND: Casein kinase II (CK2) is involved in multiple tumor-relevant signaling pathways affecting proliferation and apoptosis. CK2 is frequently upregulated in acute B-lymphoblastic leukemia (B-ALL) and can be targeted by the ATP-competitive CK2 inhibitor CX-4945. While reduced proliferation of...

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Publicado en:BMC Cancer
Autores principales: Richter, Anna, Sender, Sina, Lenz, Annemarie, Schwarz, Rico, Hinz, Burkhard, Knuebel, Gudrun, Sekora, Anett, Murua Escobar, Hugo, Junghanss, Christian, Roolf, Catrin
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2020
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7057698/
https://ncbi.nlm.nih.gov/pubmed/32131762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-020-6650-9
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