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Family reunion via error correction: an efficient analysis of duplex sequencing data

BACKGROUND: Duplex sequencing is the most accurate approach for identification of sequence variants present at very low frequencies. Its power comes from pooling together multiple descendants of both strands of original DNA molecules, which allows distinguishing true nucleotide substitutions from PC...

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Publicat a:BMC Bioinformatics
Autors principals: Stoler, Nicholas, Arbeithuber, Barbara, Povysil, Gundula, Heinzl, Monika, Salazar, Renato, Makova, Kateryna D, Tiemann-Boege, Irene, Nekrutenko, Anton
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7057607/
https://ncbi.nlm.nih.gov/pubmed/32131723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-020-3419-8
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