Dual targeting of TGF-β and PD-L1 via a bifunctional anti-PD-L1/TGF-βRII agent: status of preclinical and clinical advances

Lignende værker

• Bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with human papillomavirus-associated malignancies
  af: Strauss, Julius, et al.
  Udgivet: (2020)
• Phase I Trial of M7824 (MSB0011359C), a Bifunctional Fusion Protein Targeting PD-L1 and TGFβ, in Advanced Solid Tumors
  af: Strauss, Julius, et al.
  Udgivet: (2018)
• A novel bifunctional anti-PD-L1/TGF-β Trap fusion protein (M7824) efficiently reverts mesenchymalization of human lung cancer cells
  af: David, Justin M., et al.
  Udgivet: (2017)
• M7824, a novel bifunctional anti-PD-L1/TGFβ Trap fusion protein, promotes anti-tumor efficacy as monotherapy and in combination with vaccine
  af: Knudson, Karin M., et al.
  Udgivet: (2018)
• Analyses of functions of an anti-PD-L1/TGFβR2 bispecific fusion protein (M7824)
  af: Jochems, Caroline, et al.
  Udgivet: (2017)