Diverse Antibody Responses to Conserved Structural Motifs in Plasmodium falciparum Circumsporozoite Protein

Malaria vaccine candidate RTS,S/AS01 is based on the central and C-terminal regions of the circumsporozoite protein (CSP) of P. falciparum. mAb397 was isolated from a volunteer in an RTS,S/AS01 clinical trial, and it protects mice from infection by malaria sporozoites. However, mAb397 originates fro...

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Détails bibliographiques
Publié dans:J Mol Biol
Auteurs principaux: Pholcharee, Tossapol, Oyen, David, Torres, Jonathan L., Flores-Garcia, Yevel, Martin, Gregory M., González-Páez, Gonzalo E., Emerling, Daniel, Volkmuth, Wayne, Locke, Emily, King, C. Richter, Zavala, Fidel, Ward, Andrew B., Wilson, Ian A.
Format: Artigo
Langue:Inglês
Publié: Elsevier 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7057269/
https://ncbi.nlm.nih.gov/pubmed/31883801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2019.12.029
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