Limited Sampling Modeling for Estimation of Phenotypic Metrics for CYP Enzymes and the ABCB1 Transporter Using a Cocktail Approach

Plasma concentration data points (n = 2,640) from 16 healthy adults were used to develop and validate limited sampling strategies (LSS) for estimation of phenotypic metrics for CYP enzymes and the ABCB1 transporter, using a cocktail of subtherapeutic doses of the selective probes caffeine (CYP1A2),...

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Vydáno v:Front Pharmacol
Hlavní autoři: Coelho, Eduardo Barbosa, Cusinato, Diego Alberto Ciscato, Ximenez, João Paulo, Lanchote, Vera Lucia, Struchiner, Claudio José, Suarez-Kurtz, Guilherme
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7057125/
https://ncbi.nlm.nih.gov/pubmed/32174823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00022
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