Hormonal status affects plasma exposure of tamoxifen and its main metabolites in tamoxifen-treated breast cancer patients

BACKGROUND: Tamoxifen is considered a prodrug of its active metabolite endoxifen, which is dependent on the CYP2D6 and CYP3A enzymes. Tamoxifen pharmacokinetic variability influences endoxifen exposure and, consequently, its clinical outcome. This study investigated the impact of hormonal status on...

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Detalhes bibliográficos
Publicado no:BMC Pharmacol Toxicol
Main Authors: Ximenez, João Paulo Bianchi, de Andrade, Jurandyr Moreira, Marques, Maria Paula, Coelho, Eduardo Barbosa, Suarez-Kurtz, Guilherme, Lanchote, Vera Lucia
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6921430/
https://ncbi.nlm.nih.gov/pubmed/31852530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40360-019-0358-y
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