Concentrations of tamoxifen and its major metabolites in hormone responsive and resistant breast tumours

Patients treated with tamoxifen (TAM) for primary breast cancer often manifest de novo or acquired resistance, possibly through changes in drug metabolism. Using solid-phase extraction methods and reversed-phase high-performance liquid chromatography separations, levels of TAM and metabolites 4-hydr...

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Autors principals: MacCallum, J, Cummings, J, Dixon, J M, Miller, W R
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2000
Matèries:
Regular Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2374506/
https://ncbi.nlm.nih.gov/pubmed/10817496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2000.1120
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