Reversal Effect of ALK Inhibitor NVP-TAE684 on ABCG2-Overexpressing Cancer Cells

Failure of cancer chemotherapy is mostly due to multidrug resistance (MDR). Overcoming MDR mediated by overexpression of ATP binding cassette (ABC) transporters in cancer cells remains a big challenge. In this study, we explore whether NVP-TAE684, a novel ALK inhibitor which has the potential to inh...

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Bibliographische Detailangaben
Veröffentlicht in:Front Oncol
Hauptverfasser: Wang, Jingqiu, Wang, Jing-Quan, Cai, Chao-Yun, Cui, Qingbin, Yang, Yuqi, Wu, Zhuo-Xun, Dong, Xingduo, Zeng, Leli, Zhao, Linguo, Yang, Dong-Hua, Chen, Zhe-Sheng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Oncology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7056829/
https://ncbi.nlm.nih.gov/pubmed/32175279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.00228
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