Overexpression of ABCG2 Confers Resistance to MLN7243, a Ubiquitin-Activating Enzyme (UAE) Inhibitor

Overexpression of ATP-binding cassette transporter superfamily G member 2 (ABCG2), is known as a major mechanism mediating multidrug resistance (MDR) in cancer cells. MLN7243 is a small-molecule ubiquitin activating enzyme inhibitor currently under clinical investigation. The aim of the current stud...

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Bibliographische Detailangaben
Veröffentlicht in:Front Cell Dev Biol
Hauptverfasser: Wu, Zhuo-Xun, Yang, Yuqi, Wang, Jing-Quan, Narayanan, Silpa, Lei, Zi-Ning, Teng, Qiu-Xu, Zeng, Leli, Chen, Zhe-Sheng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Cell and Developmental Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8316815/
https://ncbi.nlm.nih.gov/pubmed/34336849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.697927
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