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Computer simulations explain mutation-induced effects on the DNA editing by adenine base editors
Adenine base editors, which were developed by engineering a transfer RNA adenosine deaminase enzyme (TadA) into a DNA editing enzyme (TadA*), enable precise modification of A:T to G⋮C base pairs. Here, we use molecular dynamics simulations to uncover the structural and functional roles played by the...
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| Udgivet i: | Sci Adv |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Association for the Advancement of Science
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7056309/ https://ncbi.nlm.nih.gov/pubmed/32181363 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz2309 |
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