Mitochondrial DNA Stimulates TLR9-Dependent Neutrophil Extracellular Trap Formation in Primary Graft Dysfunction

The immune system is designed to robustly respond to pathogenic stimuli but to be tolerant to endogenous ligands to not trigger autoimmunity. Here, we studied an endogenous damage-associated molecular pattern, mitochondrial DNA (mtDNA), during primary graft dysfunction (PGD) after lung transplantati...

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Publicado en:Am J Respir Cell Mol Biol
Autores principales: Mallavia, Beñat, Liu, Fengchun, Lefrançais, Emma, Cleary, Simon J., Kwaan, Nicholas, Tian, Jennifer J., Magnen, Mélia, Sayah, David M., Soong, Allison, Chen, Joy, Saggar, Rajan, Shino, Michael Y., Ross, David J., Derhovanessian, Ariss, Lynch, Joseph P., Ardehali, Abbas, Weigt, S. Sam, Belperio, John A., Hays, Steven R., Golden, Jeffrey A., Leard, Lorriana E., Shah, Rupal J., Kleinhenz, Mary Ellen, Venado, Aida, Kukreja, Jasleen, Singer, Jonathan P., Looney, Mark R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Thoracic Society 2020
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7055700/
https://ncbi.nlm.nih.gov/pubmed/31647878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2019-0140OC
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