Mitochondrial DNA Stimulates TLR9-Dependent Neutrophil Extracellular Trap Formation in Primary Graft Dysfunction

The immune system is designed to robustly respond to pathogenic stimuli but to be tolerant to endogenous ligands to not trigger autoimmunity. Here, we studied an endogenous damage-associated molecular pattern, mitochondrial DNA (mtDNA), during primary graft dysfunction (PGD) after lung transplantati...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Am J Respir Cell Mol Biol
Prif Awduron: Mallavia, Beñat, Liu, Fengchun, Lefrançais, Emma, Cleary, Simon J., Kwaan, Nicholas, Tian, Jennifer J., Magnen, Mélia, Sayah, David M., Soong, Allison, Chen, Joy, Saggar, Rajan, Shino, Michael Y., Ross, David J., Derhovanessian, Ariss, Lynch, Joseph P., Ardehali, Abbas, Weigt, S. Sam, Belperio, John A., Hays, Steven R., Golden, Jeffrey A., Leard, Lorriana E., Shah, Rupal J., Kleinhenz, Mary Ellen, Venado, Aida, Kukreja, Jasleen, Singer, Jonathan P., Looney, Mark R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Thoracic Society 2020
Pynciau:
Original Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7055700/
https://ncbi.nlm.nih.gov/pubmed/31647878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2019-0140OC
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