Mitochondrial DNA Stimulates TLR9-Dependent Neutrophil Extracellular Trap Formation in Primary Graft Dysfunction

The immune system is designed to robustly respond to pathogenic stimuli but to be tolerant to endogenous ligands to not trigger autoimmunity. Here, we studied an endogenous damage-associated molecular pattern, mitochondrial DNA (mtDNA), during primary graft dysfunction (PGD) after lung transplantati...

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Detalhes bibliográficos
Publicado no:Am J Respir Cell Mol Biol
Main Authors: Mallavia, Beñat, Liu, Fengchun, Lefrançais, Emma, Cleary, Simon J., Kwaan, Nicholas, Tian, Jennifer J., Magnen, Mélia, Sayah, David M., Soong, Allison, Chen, Joy, Saggar, Rajan, Shino, Michael Y., Ross, David J., Derhovanessian, Ariss, Lynch, Joseph P., Ardehali, Abbas, Weigt, S. Sam, Belperio, John A., Hays, Steven R., Golden, Jeffrey A., Leard, Lorriana E., Shah, Rupal J., Kleinhenz, Mary Ellen, Venado, Aida, Kukreja, Jasleen, Singer, Jonathan P., Looney, Mark R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7055700/
https://ncbi.nlm.nih.gov/pubmed/31647878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2019-0140OC
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