A Novel Microglia-Specific Transcriptional Signature Correlates With Behavioral Deficits in Neuropsychiatric Lupus

Neuropsychiatric symptoms of systemic lupus erythematosus (NP-SLE) affect over one-half of SLE patients, yet underlying mechanisms remain largely unknown. We demonstrate that SLE-prone mice (CReCOM) develop NP-SLE, including behavioral deficits prior to systemic autoimmunity, reduced brain volumes,...

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Bibliografiske detaljer
Udgivet i:Front Immunol
Main Authors: Makinde, Hadijat M., Winter, Deborah R., Procissi, Daniele, Mike, Elise V., Stock, Ariel D., Kando, Mary J., Gadhvi, Gaurav T., Droho, Steven, Bloomfield, Christina L., Dominguez, Salina T., Mayr, Maximilian G., Lavine, Jeremy A., Putterman, Chaim, Cuda, Carla M.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7055359/
https://ncbi.nlm.nih.gov/pubmed/32174913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00230
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