A Novel Microglia-Specific Transcriptional Signature Correlates With Behavioral Deficits in Neuropsychiatric Lupus

Neuropsychiatric symptoms of systemic lupus erythematosus (NP-SLE) affect over one-half of SLE patients, yet underlying mechanisms remain largely unknown. We demonstrate that SLE-prone mice (CReCOM) develop NP-SLE, including behavioral deficits prior to systemic autoimmunity, reduced brain volumes,...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Makinde, Hadijat M., Winter, Deborah R., Procissi, Daniele, Mike, Elise V., Stock, Ariel D., Kando, Mary J., Gadhvi, Gaurav T., Droho, Steven, Bloomfield, Christina L., Dominguez, Salina T., Mayr, Maximilian G., Lavine, Jeremy A., Putterman, Chaim, Cuda, Carla M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7055359/
https://ncbi.nlm.nih.gov/pubmed/32174913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00230
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