Neuropsychiatric Systemic Lupus Erythematosus Is Dependent on Sphingosine-1-Phosphate Signaling

About 40% of patients with systemic lupus erythematosus experience diffuse neuropsychiatric manifestations, including impaired cognition and depression. Although the pathogenesis of diffuse neuropsychiatric SLE (NPSLE) is not fully understood, loss of brain barrier integrity, autoreactive antibodies...

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Pubblicato in:Front Immunol
Autori principali: Mike, Elise V., Makinde, Hadijat M., Der, Evan, Stock, Ariel, Gulinello, Maria, Gadhvi, Gaurav T., Winter, Deborah R., Cuda, Carla M., Putterman, Chaim
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2018
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168636/
https://ncbi.nlm.nih.gov/pubmed/30319641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02189
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