Neuropsychiatric Systemic Lupus Erythematosus Is Dependent on Sphingosine-1-Phosphate Signaling

About 40% of patients with systemic lupus erythematosus experience diffuse neuropsychiatric manifestations, including impaired cognition and depression. Although the pathogenesis of diffuse neuropsychiatric SLE (NPSLE) is not fully understood, loss of brain barrier integrity, autoreactive antibodies...

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Foilsithe in:Front Immunol
Main Authors: Mike, Elise V., Makinde, Hadijat M., Der, Evan, Stock, Ariel, Gulinello, Maria, Gadhvi, Gaurav T., Winter, Deborah R., Cuda, Carla M., Putterman, Chaim
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2018
Ábhair:
Immunology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168636/
https://ncbi.nlm.nih.gov/pubmed/30319641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02189
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