Analysis of multi-lineage gene expression dynamics during primordial germ cell induction from human induced pluripotent stem cells

BACKGROUND: In mammals, specification of primordial germ cells (PGCs) is established in the early post­implantation embryo. The bone morphogenetic protein (BMP)-SMAD and WNT3-β-catenin signaling initiate the gene regulatory network for PGC specification. The activation of SOX17-BLIMP1 axis is critic...

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Published in:Stem Cell Res Ther
Main Authors: Fang, Fang, Li, Zili, Zhao, Qian, Xiong, Chengliang, Ni, Ke
Format: Artigo
Language:Inglês
Published: BioMed Central 2020
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7055065/
https://ncbi.nlm.nih.gov/pubmed/32127035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-020-01620-y
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