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Identification of Potent Pyrazole Based APELIN Receptor (APJ) Agonists

The apelinergic system comprises the apelin receptor and its cognate apelin and elabela peptide ligands of various lengths. This system has become an increasingly attractive target for pulmonary and cardiometabolic diseases. Small molecule regulators of this receptor with good drug-like properties a...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Narayanan, Sanju, Vasukuttan, Vineetha, Rajagopal, Sudarshan, Maitra, Rangan, Runyon, Scott P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7055011/
https://ncbi.nlm.nih.gov/pubmed/31948845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2019.115237
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