Identification of Potent Pyrazole Based APELIN Receptor (APJ) Agonists

The apelinergic system comprises the apelin receptor and its cognate apelin and elabela peptide ligands of various lengths. This system has become an increasingly attractive target for pulmonary and cardiometabolic diseases. Small molecule regulators of this receptor with good drug-like properties a...

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Vydáno v:Bioorg Med Chem
Hlavní autoři: Narayanan, Sanju, Vasukuttan, Vineetha, Rajagopal, Sudarshan, Maitra, Rangan, Runyon, Scott P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7055011/
https://ncbi.nlm.nih.gov/pubmed/31948845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2019.115237
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