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Transcriptional signature of prion-induced neurotoxicity in a Drosophila model of transmissible mammalian prion disease

Prion diseases are fatal transmissible neurodegenerative conditions of humans and animals that arise through neurotoxicity induced by PrP misfolding. The cellular and molecular mechanisms of prion-induced neurotoxicity remain undefined. Understanding these processes will underpin therapeutic and con...

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Detalhes bibliográficos
Publicado no:Biochem J
Main Authors: Thackray, Alana M., Lam, Brian, Shahira Binti Ab Razak, Anisa, Yeo, Giles, Bujdoso, Raymond
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7054746/
https://ncbi.nlm.nih.gov/pubmed/32108870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20190872
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