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AAV Vector Immunogenicity in Humans: A Long Journey to Successful Gene Transfer

Gene therapy with adeno-associated virus (AAV) vectors has demonstrated safety and long-term efficacy in a number of trials across target organs, including eye, liver, skeletal muscle, and the central nervous system. Since the initial evidence that AAV vectors can elicit capsid T cell responses in h...

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Bibliografski detalji
Izdano u:Mol Ther
Glavni autori: Costa Verdera, Helena, Kuranda, Klaudia, Mingozzi, Federico
Format: Artigo
Jezik:Inglês
Izdano: American Society of Gene & Cell Therapy 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7054726/
https://ncbi.nlm.nih.gov/pubmed/31972133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.12.010
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