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Exposure to wild-type AAV drives distinct capsid immunity profiles in humans
Recombinant adeno-associated virus (AAV) vectors have been broadly adopted as a gene delivery tool in clinical trials, owing to their high efficiency of transduction of several host tissues and their low immunogenicity. However, a considerable proportion of the population is naturally exposed to the...
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| Publicado en: | J Clin Invest |
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| Autores principales: | , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Clinical Investigation
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6264647/ https://ncbi.nlm.nih.gov/pubmed/30352429 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI122372 |
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