Exposure to wild-type AAV drives distinct capsid immunity profiles in humans

Recombinant adeno-associated virus (AAV) vectors have been broadly adopted as a gene delivery tool in clinical trials, owing to their high efficiency of transduction of several host tissues and their low immunogenicity. However, a considerable proportion of the population is naturally exposed to the...

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Dettagli Bibliografici
Pubblicato in:J Clin Invest
Autori principali: Kuranda, Klaudia, Jean-Alphonse, Priscilla, Leborgne, Christian, Hardet, Romain, Collaud, Fanny, Marmier, Solenne, Costa Verdera, Helena, Ronzitti, Giuseppe, Veron, Philippe, Mingozzi, Federico
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6264647/
https://ncbi.nlm.nih.gov/pubmed/30352429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI122372
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