A New Polygenic Model for Nonfamilial Colorectal Cancer Inheritance Based on the Genetic Architecture of the Azoxymethane-Induced Mouse Model

The azoxymethane model of colorectal cancer (CRC) was used to gain insights into the genetic heterogeneity of nonfamilial CRC. We observed significant differences in susceptibility parameters across 40 mouse inbred strains, with 6 new and 18 of 24 previously identified mouse CRC modifier alleles det...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Genetics
Egile Nagusiak: Bissahoyo, Anika C., Xie, Yuying, Yang, Lynda, Pearsall, R. Scott, Lee, Daekee, Elliott, Rosemary W., Demant, Peter, McMillan, Leonard, Pardo-Manuel de Villena, Fernando, Angel, Joe M., Threadgill, David W.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Genetics Society of America 2020
Gaiak:
Investigations
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7054011/
https://ncbi.nlm.nih.gov/pubmed/31879319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.119.302833
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