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Polygenic inheritance, GWAS, polygenic risk scores, and the search for functional variants
The reconciliation between Mendelian inheritance of discrete traits and the genetically based correlation between relatives for quantitative traits was Fisher’s infinitesimal model of a large number of genetic variants, each with very small effects, whose causal effects could not be individually ide...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7431089/ https://ncbi.nlm.nih.gov/pubmed/32753378 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2005634117 |
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