A New Polygenic Model for Nonfamilial Colorectal Cancer Inheritance Based on the Genetic Architecture of the Azoxymethane-Induced Mouse Model

The azoxymethane model of colorectal cancer (CRC) was used to gain insights into the genetic heterogeneity of nonfamilial CRC. We observed significant differences in susceptibility parameters across 40 mouse inbred strains, with 6 new and 18 of 24 previously identified mouse CRC modifier alleles det...

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Detalhes bibliográficos
Publicado no:Genetics
Main Authors: Bissahoyo, Anika C., Xie, Yuying, Yang, Lynda, Pearsall, R. Scott, Lee, Daekee, Elliott, Rosemary W., Demant, Peter, McMillan, Leonard, Pardo-Manuel de Villena, Fernando, Angel, Joe M., Threadgill, David W.
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2020
Assuntos:
Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7054011/
https://ncbi.nlm.nih.gov/pubmed/31879319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.119.302833
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