Toll‐like receptor 7/8‐matured RNA‐transduced dendritic cells as post‐remission therapy in acute myeloid leukaemia: results of a phase I trial

OBJECTIVES: Innovative post‐remission therapies are needed to eliminate residual AML cells. DC vaccination is a promising strategy to induce anti‐leukaemic immune responses. METHODS: We conducted a first‐in‐human phase I study using TLR7/8‐matured DCs transfected with RNA encoding the two AML‐associ...

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Detalhes bibliográficos
Publicado no:Clin Transl Immunology
Main Authors: Lichtenegger, Felix S, Schnorfeil, Frauke M, Rothe, Maurine, Deiser, Katrin, Altmann, Torben, Bücklein, Veit L, Köhnke, Thomas, Augsberger, Christian, Konstandin, Nikola P, Spiekermann, Karsten, Moosmann, Andreas, Boehm, Stephan, Boxberg, Melanie, Heemskerk, Mirjam HM, Goerlich, Dennis, Wittmann, Georg, Wagner, Beate, Hiddemann, Wolfgang, Schendel, Dolores J, Kvalheim, Gunnar, Bigalke, Iris, Subklewe, Marion
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7053229/
https://ncbi.nlm.nih.gov/pubmed/32153780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cti2.1117
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