Combined overexpression of SIRT1 and knockout of GCN5 in adult skeletal muscle does not affect glucose homeostasis or exercise performance in mice

Sirtuin 1 (SIRT1) and general control of amino acid synthesis 5 (GCN5) regulate mitochondrial biogenesis via opposing modulation of peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) acetylation status and activity. However, the combined contribution of SIRT1 and GCN5 to skeletal m...

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Bibliografiska uppgifter
I publikationen:Am J Physiol Endocrinol Metab
Huvudupphovsmän: Svensson, Kristoffer, Tahvilian, Shahriar, Martins, Vitor F., Dent, Jessica R., Lemanek, Adrianna, Barooni, Neeka, Greyslak, Keenan, McCurdy, Carrie E., Schenk, Simon
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Physiological Society 2020
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7052578/
https://ncbi.nlm.nih.gov/pubmed/31794263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00370.2019
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