Germline or inducible knockout of p300 or CBP in skeletal muscle does not alter insulin sensitivity

Akt is a critical mediator of insulin-stimulated glucose uptake in skeletal muscle. The acetyltransferases, E1A binding protein p300 (p300) and cAMP response element-binding protein binding protein (CBP) are phosphorylated and activated by Akt, and p300/CBP can acetylate and inactivate Akt, thus giv...

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Detalhes bibliográficos
Publicado no:Am J Physiol Endocrinol Metab
Main Authors: Martins, Vitor F., Dent, Jessica R., Svensson, Kristoffer, Tahvilian, Shahriar, Begur, Maedha, Lakkaraju, Shivani, Buckner, Elisa H., LaBarge, Samuel A., Hetrick, Byron, McCurdy, Carrie E., Schenk, Simon
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6620570/
https://ncbi.nlm.nih.gov/pubmed/30888860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00497.2018
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