Combined overexpression of SIRT1 and knockout of GCN5 in adult skeletal muscle does not affect glucose homeostasis or exercise performance in mice

Sirtuin 1 (SIRT1) and general control of amino acid synthesis 5 (GCN5) regulate mitochondrial biogenesis via opposing modulation of peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) acetylation status and activity. However, the combined contribution of SIRT1 and GCN5 to skeletal m...

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Veröffentlicht in:Am J Physiol Endocrinol Metab
Hauptverfasser: Svensson, Kristoffer, Tahvilian, Shahriar, Martins, Vitor F., Dent, Jessica R., Lemanek, Adrianna, Barooni, Neeka, Greyslak, Keenan, McCurdy, Carrie E., Schenk, Simon
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7052578/
https://ncbi.nlm.nih.gov/pubmed/31794263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00370.2019
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