Dexmedetomidine Protects Against Lipopolysaccharide-Induced Acute Kidney Injury by Enhancing Autophagy Through Inhibition of the PI3K/AKT/mTOR Pathway

BACKGROUND: Acute kidney injury (AKI) is often secondary to sepsis. Previous studies suggest that damaged mitochondria and the inhibition of autophagy results in AKI during sepsis, but dexmedetomidine (DEX) alleviates lipopolysaccharide (LPS)-induced AKI. However, it is uncertain whether the renopro...

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Dettagli Bibliografici
Pubblicato in:Front Pharmacol
Autori principali: Zhao, Yuan, Feng, Xiujing, Li, Bei, Sha, Jichen, Wang, Chaoran, Yang, Tianyuan, Cui, Hailin, Fan, Honggang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7052304/
https://ncbi.nlm.nih.gov/pubmed/32158395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00128
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