Dexmedetomidine Enhances Autophagy via α2-AR/AMPK/mTOR Pathway to Inhibit the Activation of NLRP3 Inflammasome and Subsequently Alleviates Lipopolysaccharide-Induced Acute Kidney Injury

BACKGROUND: Acute kidney injury (AKI) is a severe complication of sepsis; however, no effective drugs have been found. Activation of the nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome is a major pathogenic mechanism of AKI induced by lipopolysaccharide (LPS). Autophagy, a pro...

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Publicat a:Front Pharmacol
Autors principals: Yang, Tianyuan, Feng, Xiujing, Zhao, Yuan, Zhang, Haiyang, Cui, Hailin, Wei, Mian, Yang, Haotian, Fan, Honggang
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7326938/
https://ncbi.nlm.nih.gov/pubmed/32670056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00790
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