Dexmedetomidine Protects Against Lipopolysaccharide-Induced Acute Kidney Injury by Enhancing Autophagy Through Inhibition of the PI3K/AKT/mTOR Pathway

BACKGROUND: Acute kidney injury (AKI) is often secondary to sepsis. Previous studies suggest that damaged mitochondria and the inhibition of autophagy results in AKI during sepsis, but dexmedetomidine (DEX) alleviates lipopolysaccharide (LPS)-induced AKI. However, it is uncertain whether the renopro...

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Dades bibliogràfiques
Publicat a:Front Pharmacol
Autors principals: Zhao, Yuan, Feng, Xiujing, Li, Bei, Sha, Jichen, Wang, Chaoran, Yang, Tianyuan, Cui, Hailin, Fan, Honggang
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7052304/
https://ncbi.nlm.nih.gov/pubmed/32158395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00128
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