Dexmedetomidine Protects Against Lipopolysaccharide-Induced Acute Kidney Injury by Enhancing Autophagy Through Inhibition of the PI3K/AKT/mTOR Pathway

BACKGROUND: Acute kidney injury (AKI) is often secondary to sepsis. Previous studies suggest that damaged mitochondria and the inhibition of autophagy results in AKI during sepsis, but dexmedetomidine (DEX) alleviates lipopolysaccharide (LPS)-induced AKI. However, it is uncertain whether the renopro...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Zhao, Yuan, Feng, Xiujing, Li, Bei, Sha, Jichen, Wang, Chaoran, Yang, Tianyuan, Cui, Hailin, Fan, Honggang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7052304/
https://ncbi.nlm.nih.gov/pubmed/32158395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00128
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