Clarithromycin inhibits autophagy in colorectal cancer by regulating the hERG1 potassium channel interaction with PI3K

We have studied how the macrolide antibiotic Clarithromycin (Cla) regulates autophagy, which sustains cell survival and resistance to chemotherapy in cancer. We found Cla to inhibit the growth of human colorectal cancer (CRC) cells, by modulating the autophagic flux and triggering apoptosis. The acc...

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Dettagli Bibliografici
Pubblicato in:Cell Death Dis
Autori principali: Petroni, Giulia, Bagni, Giacomo, Iorio, Jessica, Duranti, Claudia, Lottini, Tiziano, Stefanini, Matteo, Kragol, Goran, Becchetti, Andrea, Arcangeli, Annarosa
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7052256/
https://ncbi.nlm.nih.gov/pubmed/32123164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2349-8
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