Clarithromycin inhibits autophagy in colorectal cancer by regulating the hERG1 potassium channel interaction with PI3K

We have studied how the macrolide antibiotic Clarithromycin (Cla) regulates autophagy, which sustains cell survival and resistance to chemotherapy in cancer. We found Cla to inhibit the growth of human colorectal cancer (CRC) cells, by modulating the autophagic flux and triggering apoptosis. The acc...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Death Dis
Prif Awduron: Petroni, Giulia, Bagni, Giacomo, Iorio, Jessica, Duranti, Claudia, Lottini, Tiziano, Stefanini, Matteo, Kragol, Goran, Becchetti, Andrea, Arcangeli, Annarosa
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7052256/
https://ncbi.nlm.nih.gov/pubmed/32123164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2349-8
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