Clarithromycin inhibits autophagy in colorectal cancer by regulating the hERG1 potassium channel interaction with PI3K

We have studied how the macrolide antibiotic Clarithromycin (Cla) regulates autophagy, which sustains cell survival and resistance to chemotherapy in cancer. We found Cla to inhibit the growth of human colorectal cancer (CRC) cells, by modulating the autophagic flux and triggering apoptosis. The acc...

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Publicat a:Cell Death Dis
Autors principals: Petroni, Giulia, Bagni, Giacomo, Iorio, Jessica, Duranti, Claudia, Lottini, Tiziano, Stefanini, Matteo, Kragol, Goran, Becchetti, Andrea, Arcangeli, Annarosa
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7052256/
https://ncbi.nlm.nih.gov/pubmed/32123164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2349-8
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