Addiction associated N40D mu-opioid receptor variant modulates synaptic function in human neurons

The OPRM1 A118G single nucleotide polymorphism (SNP rs1799971) gene variant encoding the N40D ¼-opioid receptor (MOR) has been associated with dependence on opiates and other drugs of abuse but its mechanism is unknown. The frequency of G-allele carriers is ~40% in Asians, ~16% in Europeans, and ~3%...

Full description

Saved in:
Bibliographic Details
Published in:Mol Psychiatry
Main Authors: Halikere, Apoorva, Popova, Dina, Scarnati, Matthew S., Hamod, Aula, Swerdel, Mavis R., Moore, Jennifer C., Tischfield, Jay A., Hart, Ronald P., Pang, Zhiping P.
Format: Artigo
Language:Inglês
Published: 2019
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7051890/
https://ncbi.nlm.nih.gov/pubmed/31481756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41380-019-0507-0
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items