Addiction associated N40D mu-opioid receptor variant modulates synaptic function in human neurons

The OPRM1 A118G single nucleotide polymorphism (SNP rs1799971) gene variant encoding the N40D ¼-opioid receptor (MOR) has been associated with dependence on opiates and other drugs of abuse but its mechanism is unknown. The frequency of G-allele carriers is ~40% in Asians, ~16% in Europeans, and ~3%...

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Publicado no:Mol Psychiatry
Main Authors: Halikere, Apoorva, Popova, Dina, Scarnati, Matthew S., Hamod, Aula, Swerdel, Mavis R., Moore, Jennifer C., Tischfield, Jay A., Hart, Ronald P., Pang, Zhiping P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7051890/
https://ncbi.nlm.nih.gov/pubmed/31481756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41380-019-0507-0
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