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Optimization of 8-oxoadenines with toll-like-receptor 7 and 8 activity.
Toll-like receptors 7 and 8 (TLR7/8) agonists are potent immunostimulants that are attracting considerable interest as vaccine adjuvants. We recently reported the synthesis of a new series of 2-O-butyl-8-oxoadenines substituted at the 9-position with various linkers and N-heterocycles, and showed th...
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| Veröffentlicht in: | Bioorg Med Chem Lett |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7050994/ https://ncbi.nlm.nih.gov/pubmed/32001135 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2020.126984 |
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