Synthetic Toll-like Receptors 7 and 8 Agonists: Structure–Activity Relationship in the Oxoadenine Series

[Image: see text] Toll-like receptors 7 and 8 (TLR7/8) are broadly expressed on antigen-presenting cells, making TLR7/8 agonists likely candidates for the development of new vaccine adjuvants. We previously reported the synthesis of a new series of 8-oxoadenines substituted at the 9-position with a...

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Publicado en:ACS Omega
Main Authors: Evans, Jay T., Bess, Laura S., Mwakwari, Sandra C., Livesay, Mark T., Li, Yufeng, Cybulski, Van, Johnson, David A., Bazin, Hélène G.
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2019
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6761749/
https://ncbi.nlm.nih.gov/pubmed/31572869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.9b02138
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