Novel Lipidated Imidazoquinoline TLR7/8 Adjuvants Elicit Influenza-Specific Th1 Immune Responses and Protect Against Heterologous H3N2 Influenza Challenge in Mice

Most licensed seasonal influenza vaccines are non-adjuvanted and rely primarily on vaccine-induced antibody titers for protection. As such, seasonal antigenic drift and suboptimal vaccine strain selection often results in reduced vaccine efficacy. Further, seasonal H3N2 influenza vaccines demonstrat...

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Détails bibliographiques
Publié dans:Front Immunol
Auteurs principaux: Miller, Shannon M., Cybulski, Van, Whitacre, Margaret, Bess, Laura S., Livesay, Mark T., Walsh, Lois, Burkhart, David, Bazin, Hélène G., Evans, Jay T.
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2020
Sujets:
Immunology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7075946/
https://ncbi.nlm.nih.gov/pubmed/32210973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00406
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