A novel peptide exerts potent immunosuppression by blocking the two-site interaction of NFAT with calcineurin

The calcineurin/nuclear factor of activated T cell (CN/NFAT) signaling pathway plays a critical role in the immune response. Therefore, inhibition of the CN/NFAT pathway is an important target for inflammatory disease. The conserved PXIXIT and LXVP motifs of CN substrates and targeting proteins have...

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Vydáno v:J Biol Chem
Hlavní autoři: Wang, Lu, Cheng, Na, Wang, Ping, Li, Jing, Jia, Anna, Li, Wenying, Zhang, Nan, Yin, Yanxia, Tong, Li, Wei, Qun, Liu, Guangwei, Li, Zhimei, Luo, Jing
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2020
Témata:
Enzymology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7049967/
https://ncbi.nlm.nih.gov/pubmed/31941790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010254
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